Xiaoyu Hu
Manchester
Summary
I have extensive experience in pharmacokinetic and pharmacodynamic modeling, specializing in PBPK, PKPD, and POPPK. I am proficient in developing and validating complex models using tools such as Simcyp, MATLAB, NONMEM, GastroPlus, Monolix, as well as coding in R and Matlab. My expertise includes analyzing clinical trial data, performing sensitivity analyses, designing dosing regimens, optimizing doses, and collaborating with multidisciplinary teams to integrate pharmacokinetic modeling into drug development. I possess strong skills in writing scientific reports and effectively communicating findings to stakeholders. I am eager to leverage my expertise to advance drug development at the University of Liverpool.
Overview
2
2
years of professional experience
1
1
Certification
Work History
Project: Drug Clinical Trial Data Analysis and Modeling
04.2024 - 05.2024
- Analyzed and modeled clinical trial data to assess the pharmacokinetics and pharmacodynamics of drugs using NONMEM software, developing and validating multi-compartment models
- Successfully simulated the drug's absorption, distribution, metabolism, and excretion processes, assessed the impact of gastric emptying on blood drug concentrations, and optimized model accuracy through residual error analysis and visual predictive checks (VPC)
Project: Improved Physiologically Based Pharmacokinetic (PBPK) Model Study
02.2024 - 03.2024
- Developed and validated a simplified physiologically based pharmacokinetic model that includes brain permeation constraints covering the absorption, distribution, metabolism, and excretion of drugs in human tissues
- Successfully simulated the dynamic process of the drug using MATLAB, assessing the impact of key physiological parameters on the drug concentration-time curve, and accurately predicting the behavior of drugs in the brain and other major organs
Project: Multi-Stage Pharmacodynamic-Pharmacokinetic Model Development and Data Analysis
02.2024 - 03.2024
- Led the development of a pharmacodynamic-pharmacokinetic (PK/PD) model for the drug UoM001, including simulations of the drug's absorption, distribution, metabolism, and excretion in the human body and the dynamic relationship between drug concentration and efficacy
- Successfully predicted the drug's in-body behavior and its effect on disease treatment using MATLAB and conducted extensive data processing and analysis, generating semi-logarithmic graphs and pharmacodynamic concentration curves
Project: Time-Dependent Drug-Drug Interaction Model Study
11.2023 - 01.2024
- Studied the time-dependent drug-drug interactions (TDI) between different drugs such as Midazolam and Erythromycin using a minimal physiologically based pharmacokinetic (PBPK) model to analyze enzyme activity changes in the liver and intestines
- Successfully studied the area under the curve ratio (AUC ratio) at different dosages and conducted sensitivity analysis revealing a significant impact of dosage increase on the degree of TDI and providing important parameters for drug development and clinical trial design
Project: Physiological Pharmacokinetic Modeling Study of Cefoperazone in Patients with Hepatic Insufficiency
03.2022 - 05.2022
- Developed and evaluated physiological pharmacokinetic (PBPK) models for cefoperazone in patients with varying levels of liver function using Simcyp software
- Successfully predicted pharmacokinetic parameters for patients with hepatic insufficiency, providing scientific guidance for drug dosing adjustments and offering crucial insights for the clinical use of cefoperazone
Education
Master of Science in Model-Based Drug Development -
University of Manchester
09.2024
Bachelor of Science in Pharmaceutical Sciences -
Central South University
07.2022
Skills
- PBPK modeling using Simcyp, GastroPlus
- POPPK modeling using NONMEM, and Monolix
- PKPD modelling using MATLAB, Phoenix
- Clinical trial data analysis
- Sensitivity analysis and model validation
- Advanced statistical analysis and data visualization using R
- Assessment of drug treatment plans for special population and drug-drug interaction
Certification
Third Class Scholarship of the University
Languages
Chinese (Mandarin)
Native language
English
Intermediate
B1
Timeline
Project: Drug Clinical Trial Data Analysis and Modeling
04.2024 - 05.2024
Project: Improved Physiologically Based Pharmacokinetic (PBPK) Model Study
02.2024 - 03.2024
Project: Multi-Stage Pharmacodynamic-Pharmacokinetic Model Development and Data Analysis
02.2024 - 03.2024
Project: Time-Dependent Drug-Drug Interaction Model Study
11.2023 - 01.2024
Project: Physiological Pharmacokinetic Modeling Study of Cefoperazone in Patients with Hepatic Insufficiency
03.2022 - 05.2022
Master of Science in Model-Based Drug Development -
University of Manchester
Bachelor of Science in Pharmaceutical Sciences -
Central South University
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