Reginald Ugbeyan
Dartford,Kent
Summary
Senior bioprocessing and operations leader with a strong record of GMP manufacturing, upstream process development, and quality system optimisation across biologics and ATMPs. Delivers scalable, compliant processes and consistently inspection-ready facilities while building high-performance teams and resolving complex technical challenges. Focused on operational excellence and the reliable delivery of high-quality therapeutic products.
Overview
18
18
years of professional experience
4031
4031
years of post-secondary education
Work history
Bioprocessing Team Lead
MeiraGTx
London
03.2023 - 11.2025
- Manage 6 – 14 scientists in GMP manufacture of clinical and commercial gene therapies in Grade C cleanrooms, overseeing production scheduling and ensuring safe, compliant, and consistently inspection-ready operations.
- Provide technical expertise and hands-on contribution for innovation and troubleshooting of upstream and downstream processes
- First responder for manufacturing quality issues, drive deviation initiation, root-cause analysis and CAPA implementation. Manage change controls, batch records, and audit follow-ups with right-first-time accuracy.
- Collaborate with Quality teams, Engineering and Supply Chain to align manufacturing performance with quality and regulatory expectations.
- Maintain strong GDP discipline and ensure adherence to procedures, batch execution steps, and documentation controls. Review and approve BMRs ready for QP batch release.
- Liaise with senior management on strategic planning initiatives, production schedules and contribute valuable insights to successful project outcomes.
- Conduct regular progress reviews, appraisals with individual team members to identify areas for improvement and provide guidance on career development opportunities.
Fermentation Team Lead
FabricNano
London
08.2021 - 12.2022
- Established new in-house fermentation capability, led development and optimisation of scalable process from batch-batch (1 L) to fed-batch (40 L) FabricNano's E. coli platform process.
- Reduced outsourcing of enzyme production by >80% and production turnaround times from 4 weeks to 1 week.
- Designed, implemented, and validated processes for novel bioreactor formats and monitoring metrics for enzyme activity, functionality and fusion-tag conjugation to ensure reproducibility.
- Increased team productivity from 2 to 6 enzymes per week through process optimisation and workflow redesign.
- Contributed to development of patent, enhancing organisation's intellectual property portfolio.
Lead Scientist
Lonza Biologics plc
Slough
09.2018 - 06.2021
- Delivered process development activities for monoclonal antibody biological licence application (BLA) submissions and process limit evaluation (PLE) studies.
- Led cross-functional teams to successfully scale-up from 10 L to 100 L for therapeutic monoclonal antibodies production on CHOK1-Gens and GS-KO platforms.
- Managed multiple scale-down model assessments using ambr250 to mimic 10 L production bioreactors to deliver customer projects.
- Prepared high-quality documentations with ELNs, LIMs, reports, and client-ready presentations, ensuring regulatory alignment.
- Coordinated interdisciplinary efforts between various departments allowing for more streamlined approaches towards reaching customer deliverables.
Process Development Scientist
Cell and Gene Therapy Catapult
London
09.2013 - 08.2017
- Led successful technology transfer from pilot scale to full-scale manufacturing of WT-1 TCR gene dosage form for Great Ormond Street Hospital.
- Developed workflows for mesenchymal cell platforms on serum-free media using GE Xuri W25 bioreactors for seed inoculum trains.
- Helped to established initial lentiviral and AAV vector process development capabilities through clonal screening and selection.
- Applied design of experiment (DoE) and quality by design (QbD) tools to reduce variability and increase output by 40% in bench-top bioreactors.
- Led and collaborated on development studies for Catapult's CellSTACK programme and Quantum hollow fibre systems to evaluate cell proliferation and measure mAbs activities.
Production Team Leader
RMS Innovations (UK) Limited
Elstree, Hertfordshire
12.2009 - 08.2013
- Ensured on-time delivery of autologous chondrocytes, osteocytes by rigorously following production timelines.
- Led and managed production scientists, technicians, 2 Grade C cleanroom facilities to consistently meet deadlines and deliverable goals.
- Investigated quality, safety and productivity issues, implementing corrective action to prevent recurrence.
- Improved completion of BMR records and reviews by 45% through effective planning and redesign of production schedules.
- Evaluated employee skills and knowledge regularly, training, and mentoring individuals with lagging skills.
Study Scientist
Huntingdon Life Sciences
Huntingdon, Cambridgeshire
01.2008 - 11.2009
- Simultaneously managed 3 client clinical studies, meeting all pertinent milestones and deadlines.
- Carried out day-to-day duties including cell culture, transfection and flow cytometry analysis accurately and efficiently.
- Completed client reports to deliver on targets with accuracy and efficiency and presented project findings.
- Performed complex troubleshooting and assisted in leading initiatives to solve challenging scientific problems with assays or instrumentation.
Education
Bachelor of Science - Biomedical Engineering and Forensic Biology
Manchester Metropolitan University
Certificate of Higher Education - Advance Course Microbial Physiology and Fermentation Technology
Delft University of Technology
Skills
- GMP leadership
- Manufacturing process optimisation
- Proficient in ATMP production
- Quality assurance management
- Change control oversight
- Upstream optimisation techniques
- Technology transfer
- Expertise in process scaling
- Team leadership
- Audit readiness evaluation
- Understanding of regulatory standards
- Cross-team collaboration
- Application of lean principles
- KPI analysis
Interests
- Art exhibitions
- Biographies & documentaries
- History museums
- Galleries
- Travel
- Films & TV shows
References
References available upon request.
Timeline
Bioprocessing Team Lead
MeiraGTx
03.2023 - 11.2025
Fermentation Team Lead
FabricNano
08.2021 - 12.2022
Lead Scientist
Lonza Biologics plc
09.2018 - 06.2021
Process Development Scientist
Cell and Gene Therapy Catapult
09.2013 - 08.2017
Production Team Leader
RMS Innovations (UK) Limited
12.2009 - 08.2013
Study Scientist
Huntingdon Life Sciences
01.2008 - 11.2009
Bachelor of Science - Biomedical Engineering and Forensic Biology
Manchester Metropolitan University
Certificate of Higher Education - Advance Course Microbial Physiology and Fermentation Technology
Delft University of Technology