Summary
Overview
Work history
Education
Skills
References
Honours
Affiliations
Accomplishments
Languages
Timeline
Generic

Madhavi Harish

Didcot,UK

Summary

Accomplished professional with extensive expertise in PK/PD bioanalysis and in vitro ADME assays, delivering high-quality reports through precise sample processing and reliable assay execution. Demonstrates strong analytical rigour and attention to detail, supporting data-driven pharmacokinetic conclusions. Proficient in LC-MS method development, including chromatographic optimisation and MS tuning, ensuring robust and transferable methods. Skilled in cell culture techniques for Caco-2 and MDCK cells under aseptic conditions. Provides project-specific support as Deputy Project Representative, ensuring timely delivery aligned with project timelines. Co-leads quality compliance activities, maintaining audit readiness and regulatory alignment. Proficient in software tools such as Morphit & Biorails, Spotfire, WinNonlin, Excel, MassLynx, Analyst, Sciex OS, LIMS, Word, PowerPoint, Teams, and SharePoint.

Overview

19
19
years of professional experience
5
5
years of post-secondary education

Work history

Scientist 1 DMPK

Evotec Ltd
Oxford, Oxfordshire
2023.01 - 2026.04
  • Assisted in conducting routine bioanalytical techniques, including sample extraction and assay setup.
  • Supported analytical data interpretation to contribute to high-quality study outputs.
  • Collaborated with team members to maintain effective communication and organisation.

Scientist DMPK

Evotec Ltd
Oxford, Oxfordshire
2020.01 - 2023.01
  • Conducted routine and non-routine analyses of test samples, including biofluids and tissues.
  • Assisted in bioanalysis of small molecules for various clients, interpreting data to calculate pharmacokinetic parameters using WinNonlin.
  • Supported execution of unconventional studies involving multiple matrices and dosing routes, demonstrating adaptability in challenging scenarios.

LC MS analytical role

  • Assisted in troubleshooting issues with responsible instruments to ensure smooth operation of invitro and bioanalytical workflows.
  • Participated as a member of the analytical super-user group to enhance technical knowledge regarding LC/MSMS techniques.
  • Contributed to instrument maintenance activities for all SCIEX Triple Quadrupole Mass Spectrometers and Waters instruments.
  • Assisted in initial cell preparation for hepatocyte stability assay.
  • Utilised hemocytometer for accurate cell counting.
  • Supported maintenance of aseptic conditions for cell culture.

Lab technician

Evotec Ltd
Oxford, Oxfordshire
2018.01 - 2020.01

Achieved compliance with waste management regulations through effective coordination of daily waste disposal activities.
Enhanced laboratory efficiency by maintaining optimal stock levels of consumables and reagents.
Streamlined buffer preparation processes, resulting in improved laboratory workflow.
Optimised DMPK assay management, ensuring timely availability of substrates and compounds.
Delivered consistent maintenance of analytical instruments, ensuring reliable performance and accurate results.

Nursery teaching assistant

Bright Horizons
Milton, Oxfordshire
2018.02 - 2018.08
  • Assisted in the preparation of teaching materials, enhancing lesson delivery.
  • Planned age-appropriate games that helped develop physical coordination amongst children.
  • Participated in staff meetings to discuss child progress and plan future lessons.
  • Developed strong relationships with parents to foster child development and growth.

Health care assistant ( part time )

Bupa Care Homes
Colchester, Essex
2011.06 - 2017.12
  • Assisted in delivering patient care to improve comfort and well-being.
  • Escorted patients to tests or procedures within hospital premises while ensuring safety and comfort.
  • Maintained patient confidentiality consistently while performing duties in accordance with data protection norms set by NHS.
  • Cared for individuals suffering from dementia and Huntington's disease.

Clinical laboratory assistant

Micro Biological Lab
Coimbatore, India
2007.06 - 2009.07

Assisted with training activities in phlebotomy department.

Supported automated antibody assays in virology.

Contributed to compliance with procedural standards.

Education

MSc - Biochemistry

University of Bharathiar
India
2005.01 - 2007.01

BSc - Biochemistry

University of Bharathiar
India
2002.01 - 2005.01

Skills

  • Deliver high-quality PK/PD bioanalysis reports for small molecules through precise sample processing, reliable assay execution, detailed interpretation of LC-MS data, and application of NCA, demonstrating strong analytical rigour and high attention to detail to support clear, data-driven pharmacokinetic conclusions
  • Expertise in invitro ADME assays including MDCK permeability, brain and tissue binding, and plasma stability, supported by strong assay reproducibility, rapid adaptation to new protocols, and hands-on experience with robotic platforms enabling high-throughput workflows
  • Skilled in cell culture maintaining, passaging, and preparing Caco-2 and MDCK cells under strict aseptic conditions to ensure consistent, high-quality cultures for in vitro ADME assays
  • Support analytical workflows through LC-MS instrumentation, including hands-on operation and routine maintenance of Sciex and Waters systems
  • Expertise in LC-MS method development for small-molecule bioanalysis, including selective extraction, chromatographic optimisation, MS tuning, and validation across diverse matrices Skilled in assessing ionisation behaviour, minimising matrix effects, optimising sample prep (protein precipitation, SPE), and troubleshooting chromatographic or MS performance to ensure robust, transferable, and stable methods
  • Led method development to assess the impact of PEG removal using SPE, identifying that the approach lacked reproducibility Evaluated alternative assays, performed detailed data analysis, and provided evidence-based recommendations to discontinue the method and adopt a more suitable analytical strategy
  • Provide project-specific support as Deputy Project Representative, contributing to PK project coordination, compound ordering and shipment management, report summarisation and execution of IVIVC-related data workflows, ensuring accurate and timely delivery aligned with project timelines
  • Expertise in quality compliance, co-leading quality activities for the department, including timely completion of CAPAs, thorough SOP reviews, and accurate documentation updates to maintain audit readiness and ensure alignment with regulatory and internal quality standards
  • Morphit & Biorails software
  • Spotfire
  • WinNonlin
  • Excel (advanced functions, pivot tables, data cleaning)
  • MassLynx, Analyst, Sciex OS, LIMS
  • Word, PowerPoint, Teams, SharePoint

References

  • Joanne, Sproston, VP, Drug Metabolism and Pharmacokinetics, Joanne.Sproston@evotec.com, DMPK, Evotec (UK) Ltd, Oxfordshire, OX14 4RZ
  • Rachel, Bush, Team Leader, Rachel.Bush@evotec.com, DMPK, Evotec (UK) Ltd, Oxfordshire, OX14 4RZ

Honours

Multiple-time recipient of Evo recognition silver and bronze awards, recognising sustained high performance and consistent contribution to team success.

Affiliations

  • Singing ,dancing,travelling,cooking &baking

Accomplishments

Evo recognition awards:

Silver – for managing Pipette clinic for the entire site with out disruption of any workflow along with managing routine responsibilities

Bronze for going beyond the role & supporting both Invitro & BioA during crucial period.

A few team awards for some projects & also for supporting biweekly Invitro submission

Languages

English
Fluent
Hindi
Fluent
Tamil
Fluent
Malayalam
Native

Timeline

Scientist 1 DMPK

Evotec Ltd
2023.01 - 2026.04

Scientist DMPK

Evotec Ltd
2020.01 - 2023.01

Nursery teaching assistant

Bright Horizons
2018.02 - 2018.08

Lab technician

Evotec Ltd
2018.01 - 2020.01

Health care assistant ( part time )

Bupa Care Homes
2011.06 - 2017.12

Clinical laboratory assistant

Micro Biological Lab
2007.06 - 2009.07

MSc - Biochemistry

University of Bharathiar
2005.01 - 2007.01

BSc - Biochemistry

University of Bharathiar
2002.01 - 2005.01
Madhavi Harish