Summary
Overview
Work history
Education
Skills
Languages
Publications
Timeline
Generic

Laura Chan Wah Hak

London

Summary

I am an experienced Senior Research Scientist, specialised in cellular and molecular biology, with a passion for early drug discovery and a focus on oncology. I have successfully led projects, and I am looking for a new challenge as a Lab Manager, where I can apply my expertise in drug discovery and development.

Overview

9
9
years of professional experience
11
11
years of post-secondary education

Work history

Senior Scientist

Engitix Therapeutics
London
01.2021 - Current
  • Supported Operations Team with continuous improvement of laboratory and health & safety procedures (Health & Safety Rep)
  • Liaised with suppliers for purchase of reagents and engineers for the maintenance and repairs of equipment
  • Worked closely with the Senior Management Team on the implementation of a fully automated analytical and cell culture system (Automation Superuser)
  • Trained scientists on the use of various equipment and techniques
  • Developed and optimised 3D ECM-hydrogel cell-based assays for target validation
  • Independently planned and performed various tasks simultaneously
  • Summarised data concisely and presented in internal and external meetings
  • Set up and led a Social and Wellbeing Committee and organised company-wide events

PostDoctoral Training Fellow

Institute of Cancer Research
London
01.2019 - 12.2020
  • Worked with several teams to ensure smooth relocation of the lab
  • Established HTS cascade to screen more than 1000 small molecules and to identify potential clinical candidates for the treatment of cancers
  • Carried out target deconvolution and determination of SAR in collaboration with the Proteomics Team
  • Developed, optimised and executed assays to elucidate mechanism of action of a putative therapeutic target: 2D and 3D migration and invasion assays, cell cycle profiling using flow cytometry
  • Contributed to the launch of a spin-out company (Monte Rosa Therapeutics)

DPhil Student

University of Oxford
Oxford, Oxfordshire
09.2014 - 12.2018
  • Established a working cell culture environment and implemented various techniques in the lab
  • Analysed protein-DNA interactions using ChIP and DamID and DNA sequencing
  • Trained Masters students on various techniques, including cell culture, cloning, Western Blotting and reporter assays


Junior Dean

Corpus Christi College, Oxford
Oxford, Oxfordshire
01.2016 - 09.2018
  • Assumed responsibility for the welfare and discipline of 300 students
  • Ensured compliance with college rules and regulations
  • Attended monthly meetings with senior members of the college to discuss student matters
  • Trained as a First Aider, Mental Health First Aider and a Fire Warden
  • Responsible for supplying food for 200 students and organising monthly termly dinners for students, guests and staff

Education

Doctor of Philosophy - Ion Channels in Health and Disease

University of Oxford
Oxford, Oxfordshire
09.2014 - 09.2018

Master of Science - Biosciences

University College London
London
09.2013 - 09.2014

Bachelor of Science - Biochemistry

University College London
London
09.2010 - 09.2013

A-Levels -

Loreto College Quatre Bornes
Mauritius
01.2007 - 12.2009

Skills

    Professional Skills:

  • Well versed in Ms Office, Shell Scripts, Python, R, and Perl
  • Experience working with GraphPad Prism, Geneious, Dotmatics and Benchling
  • Ability to build and foster good working relationships and work efficiently in a team
  • Ability to work under pressure and to tight deadlines
  • Highly organised and detail-oriented
  • Training and mentoring of staff


    Scientific Skills:

  • Gene editing using CRISPR-Cas9 gene editing system
  • Stable cell line generation using lentiviral transductions
  • Transcription assays: Luciferase assays and qRT-PCR
  • 2D and 3D cell culture
  • High-throughput screening
  • Assay development and optimisation
  • Target validation: siRNA/shRNA and Western blot

Languages

English
Native
French
Native

Publications

  • Dendritic integration of sensory information in perceptual decision-making (Cell, April 2018)
  • FBP17 and CIP4 recruit SHIP2 and Lamellipodin to prime the plasma membrane for Fast Endophilin-Mediated Endocytosis (Nature Cell biology, July 2018)
  • Cdk5 and GSK3β inhibit fast endophilin-mediated endocytosis (Nature Communications, 2021)
  • SimPLIT: Simplified sample preparation for large-scale isobaric tagging proteomics (J. Proteome Res., 2022)

Timeline

Senior Scientist

Engitix Therapeutics
01.2021 - Current

PostDoctoral Training Fellow

Institute of Cancer Research
01.2019 - 12.2020

Junior Dean

Corpus Christi College, Oxford
01.2016 - 09.2018

DPhil Student

University of Oxford
09.2014 - 12.2018

Doctor of Philosophy - Ion Channels in Health and Disease

University of Oxford
09.2014 - 09.2018

Master of Science - Biosciences

University College London
09.2013 - 09.2014

Bachelor of Science - Biochemistry

University College London
09.2010 - 09.2013

A-Levels -

Loreto College Quatre Bornes
01.2007 - 12.2009

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Laura Chan Wah Hak