Yunjia Chang
Undergraduate
York,United Kingdom
Summary
A motivated and committed third-year Biology student at University of York with strong academic achievement, proficiency in bioinformatics analysis and a wide range of laboratory skills. Keen to learn new skills and topics. Interested in evolutionary biology and bioinformatics and look forward to applying skills to solve real biological questions.
Overview
6
6
years of professional experience
7
7
years of post-secondary education
3
3
Languages
Work History
Stage 4 Research Project
University of York
York, North Yorkshire
10.2023 - Current
- Using zebrafish to investigate the pathology of Krabbe disease, a type of leukodystrophy that is caused by mutations in galc gene
- Working with stable galca/b mutant zebrafish line and wild type zebrafish with disrupted galca/b genes with CRISPR/Cas9 system.
- Applying live dye called acridine orange that can stain apoptotic cells and lysosomes to assess apoptosis events in the brain of zebrafish embryos at early developmental stage (1, 3 and 4 dpf)
- Using fluorescence microscope and confocal microscope to capture and analyse fluorescence signals in Fiji
- Extract DNA from zebrafish to confirm their genotype and map to phenotype data
NERC Summer Internship
Natural Environment Research Council (NERC)
York, North Yorkshire
07.2023 - 09.2023
- Use Chetone histrio moths which show Müllerian mimicry of warning colour patterns to study the genetic mechanisms of convergent evolution
- Generated a dataset of categorical/near categorical traits from two populations of Chetone histrio moths
- Three continuous traits are quantified using packages in Rstudio and tools in Photoshop
- Performed GWAS analysis to assess any association between the continuous traits and SNPs
- Provided workflow for further investigations
Stage 3 Research Project
University of York
York, United Kingdom
10.2022 - 04.2023
- A collaborative project to test the potential of a microbial metabolic assay using resazurin to measure the amount of viable microorganisms transferring from gloves onto fabrics
- Used spectrophotometry to estimate the number and metabolic activity of E. coli
- Identified issues with experimental methods to improve data accuracy
Sequence Analysis Report
University of York
York, United Kingdom
10.2022 - 01.2023
- An independent bioinformatics project
- Performed GWAS analysis on 17 samples of L. infantum and L. donovani from 4 different sites to examine their population structure and identify origins of unknown samples
- Used various tools in Galaxy to align genome samples against a reference genome and identify SNPs/indels sites
- Performed PCA analysis and calculated nucleotide diversity in Rstudio
- Carried out optional ploidy analysis and produced a corresponding heatmap using R
Bio-X Research Institute
Shanghai Jiao Tong University
Shanghai, China
06.2019 - 07.2019
- Shadowed a Masters student's research project
- First encountered with bioinformatics (analysed tumour data from TCGA in Rstudio)
- Learned about cell culturing techniques
- Operated PCR machines and micro-volume UV-Vis spectrophotometer
- Developed a meaningful and close relationship with the Master student
Antibiotics Unearth
Microbiology Society
Stevenage, United Kingdoms
04.2018 - 05.2018
- Collected soil samples and analysed the potential to provide new antibiotics
- Carried out a series of lab work including Gram staining
Education
Integrated Masters in Biology -
University of York
York 09.2020 - Current
High School Diploma -
St. Francis College
Letchworth Garden City 09.2016 - 06.2020
Skills
LFA Japanese lessons
undefinedTimeline
Stage 4 Research Project
University of York
10.2023 - Current
NERC Summer Internship
Natural Environment Research Council (NERC)
07.2023 - 09.2023
Stage 3 Research Project
University of York
10.2022 - 04.2023
Sequence Analysis Report
University of York
10.2022 - 01.2023
Integrated Masters in Biology -
University of York
09.2020 - Current
Bio-X Research Institute
Shanghai Jiao Tong University
06.2019 - 07.2019
Antibiotics Unearth
Microbiology Society
04.2018 - 05.2018
High School Diploma -
St. Francis College
09.2016 - 06.2020
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