Yana Sizentsova
Norwich,The UK
Overview
10
10
years of professional experience
12
12
years of post-secondary education
Work history
The PostDoc Researcher
The Earlham Institute
Norwich, the United Kingdom
05.2023 - 05.2024
The development of cutting-edge spatial transcriptomics approach for studying circadian clocks at single-cell resolution in Arabidopsis and wheat
Researcher
Radboud University for Biological and Environmental Science
Nijmegen, The Netherlands
05.2021 - 04.2023
- Generation of knock-out mutants of predicted cold stress regulators, stem cell niche phenotypical analysis in response to low temperature treatment
Junior Researcher
Institute of Cytology and Genetics
Novosibirsk
01.2018 - 03.2021
- RNA-seq and microarray data analysis for identification of cold stress-regulated genes, promoter analysis for detection of cold stress upstream regulators (transcription factors)
Research assistant
Institute of Molecular and Cellular Biology
Novosibirsk
01.2015 - 01.2018
- Generation of T-cells expressing chimeric antigen receptor against humor cancer antigens and their cytotoxic and activation assay
Laboratory assistant
Institute of Cytology and Genetics
Novosibirsk
01.2014 - 01.2015
- Antibiotic and medium preparation, qPCR analysis of antioxidant enzymes and their protein detection using Western blot in parasitic trematode Opisthorchis felineus
Education
Bachelor - Biology
Novosibirsk State University
01.2011 - 05.2015
Master - Genetics
Novosibirsk State University
01.2015 - 05.2017
PhD - genetics/molecular plant physiology
Radboud University for Biological and Environmental Science and Institute of Cytology and Genetics
01.2018 - 03.2023
Skills
- R programming
- Statistics and data analysis
- Molecular lab skills: molecular cloning, RNA extraction and qPCR analysis, CRISPR/Cas9-mediated gene knockout
- Bioinformatics: RNA-seq data processing, DNA motif analysis
- Fluorescent and confocal microscopy
- Phenotypical analysis
Languages
English
Upper intermediate
Russian
Proficient (C2)
TEACHING
Bachelor internship, Daily supervisor
2022 – 2023 | RIBES, Nijmegen
I guided my student in performing phenotypical root analysis, generation of reporter lines, RNA extraction and qPCR analysis of cold stress-regulated genes
Project: "Role of KUA1-like members in root thermogenesis of Arabidopsis thaliana"
Genomics, Course Assistant
2020 | RIBES, Nijmegen
I helped to teach students basic bioinformatical methods: introduction to NCBI and UCSC Genome Browser, gene and protein alignment, search of homologs, phylogenetic analysis in MEGA
Bachelor internship, Daily supervisor
2020 – 2021 | Novosibirsk State University, Novosibirsk
I guided my bachelor student to do DNA motif analysis of promoters and phylogenetic analysis of nucleotide and protein sequences
Project: "Search for new potential cold stress regulators among MYB-like transcription factors in Arabidopsis thaliana"
PUBLICATIONS
Architecture of DNA elements mediating ARF transcription factor binding and auxin-responsive gene expression in Arabidopsis, PNAS, 2020. Freire-Rios A, Tanaka K, Crespo I, van der Wijk E, Sizentsova Y, Levitsky V, Lindhoud S, Fontana M, Hohlbein J, Boer DR, Mironova V, Weijers D
metaRE R Package for Meta-Analysis of Transcriptome Data to Identify the cis-Regulatory Code behind the Transcriptional Reprogramming, Genes, 2020. Novikova D, Cherenkov P, Sizentsova Y, Mironova V
Meta-Analysis of Transcriptome Data Detected New Potential Players in Response to Dioxin Exposure in Humans, International Journal of Molecular Sciences, 2020. Oshchepkova E†, Sizentsova Y†, Wiebe D, Mironova V, Kolchanov N
† - equal contribution
CONFERENCES
- ColdOmics: integrative approach to identify cold stress regulators in Arabidopsis thaliana, Annual Meeting Experimental Plant Sciences, 2022, Lunteren, oral report
- Meta-analysis of transcriptome data clarified hormonal regulation of cold stress response in Arabidopsis thaliana L., The Twelfth International Multiconference "BGRS/SB-2020", 2020, Novosibirsk, oral report
- Development of cell line stable expressing chimeric antigen receptors with antigen-recognition part based on the 10th domain of fibronectin III type, International Scientific Student Conference, 2016, Novosibirsk, oral report
Timeline
The PostDoc Researcher
The Earlham Institute
05.2023 - 05.2024
Researcher
Radboud University for Biological and Environmental Science
05.2021 - 04.2023
Junior Researcher
Institute of Cytology and Genetics
01.2018 - 03.2021
PhD - genetics/molecular plant physiology
Radboud University for Biological and Environmental Science and Institute of Cytology and Genetics
01.2018 - 03.2023
Research assistant
Institute of Molecular and Cellular Biology
01.2015 - 01.2018
Master - Genetics
Novosibirsk State University
01.2015 - 05.2017
Laboratory assistant
Institute of Cytology and Genetics
01.2014 - 01.2015
Bachelor - Biology
Novosibirsk State University
01.2011 - 05.2015
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