Sofia Azam

Personal Profile A motivated and diligent healthcare analyst with a passion for health tech and extensive experience in qualitative and quantitative research, data/information management, and business intelligence. Educated with an MSc in Biomedical Research from Imperial College London and professional experience in the pharmaceutical and financial industries. Confident in analysing problems and effectively communicating with cross-functional and geographically dispersed stakeholders to implement data related strategies, establish business needs, and build client relationships. With over two years of advisory and project management experience in industry-leading and emerging companies across various public and private sectors. I now seek a dynamic role in a reputable and forward-thinking organisation.

Suppressor CD4+ T cells expressing HLA-G are expanded in the peripheral blood from patients with acute decompensation of cirrhosis Suppressor CD4+ T cells expressing HLA-G are expanded in the peripheral blood from patients with acute decompensation of cirrhosis

Gut · Aug 3, 2021Gut · Aug 3, 2021

• This work has established the role of the anti-inflammatory cytokine IL-35 in inducing the HLA-G+ phenotype in patients with AD. Furthermore, although secreted by the HLA-G+ cells, higher levels of IL-35 seemed to originate in KCs following challenge from LPS. We, therefore, postulate that continuous exposure to gut-derived bacterial products through increased bacterial translocation in AD47 is likely to explain the induction and release of IL-35 from specialised cells in the inflamed liver that can reach the circulation.