Shakanna Muruganandan

• Designed and executed customized assays aligned with client specifications under tight timelines.
• Cross-trainer/Reviewer for tech transfer of assays to QC team for GMP.
• Led report generation and data interpretation for internal and external stakeholders.
• Trained junior staff and enhanced workflow efficiency through lab strategy optimization.
• Applied statistical tools for data analysis and supported transition planning toward ddPCR implementation.
• Implemented safety protocols in lab settings, reducing potential risks.
• Facilitated training programmes, enhancing staff skills and knowledge.

• Managed CMC analytical activities, including assay development, qualifications,validation, and DOE implementation.
• Performed/Trained ELISA, HPLC, DLS, Nanosight, and cell-based assays for release and stability testing.
• Reviewed and authored SOPs and technical documents in compliance with GMP standards.
• Led analytical tech transfer to CROs/CMOs and collaborated across functional teams for IND submissions.
• Supported projects requiring cellular heterogeneity analysis, with familiarity in workflows underpinning single-cell analysis and ddPCR approaches
• Created spreadsheets and other forms of documentation to accurately record and calculate analytical results.

• Experience in handling genetically modified organisms e.g. viral vectors e.g. Adenovirus, Modified Vaccinia Ankara.
• Conducted routine testing and qualification of viral vectors and cellular therapies.
• Performed molecular assays (PCR, qPCR), protein quantification, microscopy, and flow cytometry.
• Supported method transfer and qualification for critical assays including PicoGreen and NTA.
• Ensured compliance with safety regulations through COSHH documentation and lab audits.

.

• Led multiple concurrent projects focused on ocular and neurological gene therapy.
• Developed and executed molecular and cellular biology protocols, including cloning and RT-qPCR.
• Carried out protein biochemistry techniques such as ELISA and Western Blotting.
• Maintained GMP standards and presented findings in internal and external meetings