Summary
Overview
Work History
Education
Skills
References
Timeline
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Sarah Griffiths

Henlow,Bedfordshire

Summary


An accomplished Cell Biologist with over 20 years of industrial experience in drug discovery research. Expertise in designing, robust cellular based in-vitro assays, analysing complex datasets, and delivering actionable insights to advance scientific understanding. Proven track record of collaborating with multidisciplinary teams, fostering innovation, and contributing to the successful progression of research projects.

Overview

24
24
years of professional experience
8
8
years of post-secondary education

Work History

Principal Scientist

Benevolent AI
, Cambridge
02.2022 - Current
  • Design, develop and execute robust In-vitro cell based assays
  • Validate novel targets identified from Benevolent’s AI pipeline
  • Evaluate compound libraries including PROTACS through target specific cell based assays
  • Effective communication of scientific findings in project team meeting and report writing
  • Liaise with a various CROs to outsource cellular and biochemical assays
  • Collaborate closely with biology and chemistry leads, to design and implement effective cellular screening cascades
  • Pivotal role in cellular assay troubleshooting within Benevolent
  • Provided training and professional growth of employees through line management and mentoring
  • Work with data enabling team to insure that screening data is captured and processed correctly

Senior Scientist

Benevolent AI
Cambridge
09.2019 - 02.2022
  • Streamlined processes & reproducible by implementing laboratory automation
  • Design, develop and execute robust In-vitro cell based assays
  • Validate novel targets identified from Benevolent’s AI pipeline
  • Evaluate compound libraries through target specific cell based assays
  • Collaborated across multidisciplinary address research needs and objectives
  • Facilitated the smooth day to day running of category 1 tissue culture suite
  • Kept risk assessments and standard operating procedures up to date

Scientist

Cancer Research UK Therapeutic Discovery labs
, Cambridge
11.2007 - 09.2019
  • Evaluation of compound libraries through cell based assays
  • Validation of novel oncology targets
  • Evaluation of compound libraries in combination assays with Standard of Care agents
  • Use of live cell imaging and high content cell based instrumentation
  • Data analysis & report writing

Research scientist

Spirogen,
London
03.2004 - 11.2007
  • Evaluation of compound libraries through cell and gel based DNA assays
  • Departmental Radiation Protection Supervisor

Research scientist

Cambridge Antibody Technology
Cambridge
05.2001 - 03.2004
  • High throughput screening of single chain fragments and monoclonal antibody libraries
  • Target specific bioassay development

Technician

Zetagen
Hatfield
07.2000 - 05.2001
  • Assisted with the research and development of the company’s rapid microbial identification kits

Education

Master of Science - Infectious Disease

London School of Hygiene and Tropical Medicine
University of London
09.2006 - 08.2009

Bachelor of Science - Molecular Biology

University of Hertfordshire
Hatfield
09.1995 - 07.2000

Skills


Tissue Cell Culture

  • Continuous and Primary cell culture
  • Human and murine cell lines Stable transfected cell lines


Cellular based assays

  • In-cell ELISA
  • ELISA
  • HTRF
  • AlphaLISA
  • Promega NanoBRET & HiBit Systems
  • High Content Immunofluorescence
  • IncuCyte based assays
  • Reporter gene assays


Cell Health assays

  • Viability (2D & 3D)
  • Proliferation
  • Apoptosis assays


Molecular Biology techniques

  • RNA -Seq
  • Nucleic acid isolation
  • PCR, RT-qPCR,
  • Western blot analysis
  • MSD
  • siRNA knockdown
  • Alt-R CRISPR-Cas9 system
  • Target engagement assays


Automation

  • Liquid handling robotics
  • Plate readers


Data Analysis Software

  • Dotmatics
  • ActivityBase
  • GraphPad Prism
  • BMG MARS
  • Combination studies software



References

References available upon request.

Timeline

Principal Scientist

Benevolent AI
02.2022 - Current

Senior Scientist

Benevolent AI
09.2019 - 02.2022

Scientist

Cancer Research UK Therapeutic Discovery labs
11.2007 - 09.2019

Master of Science - Infectious Disease

London School of Hygiene and Tropical Medicine
09.2006 - 08.2009

Research scientist

Spirogen,
03.2004 - 11.2007

Research scientist

Cambridge Antibody Technology
05.2001 - 03.2004

Technician

Zetagen
07.2000 - 05.2001

Bachelor of Science - Molecular Biology

University of Hertfordshire
09.1995 - 07.2000

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