Oliver Hickman
London
Summary
Committed, creative and experienced life-scientist with a strong background in cancer research, drug-target discovery, small-molecule and genetic screening and validation. I have 15 years experience developing and leading projects in a range of disciplines, a strong focus on innovative solutions for difficult problems. I have outstanding communication skills, a drive for excellence, and willingness to take on added responsibilities to meet team goals.
Overview
15
15
years of professional experience
Work History
Postdoctoral Fellow
Institute Of Cancer Research
10.2017 - Current
Collaboration with Astrazeneca, setting up a large small-molecule screen to identify novel drug-resistance targets in ER+ breast cancer
Initiation and execution of a study to identify novel senolytics and have identified a novel senolytic/senolytic modality (patenting ongoing)
Identification of sythetic lethal factors in novel anti-cancer targets of interest.
- Designed robust experiments that produced reliable data, enabling accurate interpretation of results.
- Maintained records of research findings with analysis and evaluation of results.
- Authored professional scientific papers for publishing in peer-reviewed journals.
- Evaluated emerging technologies for potential applications within ongoing research projects, staying at the forefront of scientific advancements.
Postdoctoral Researcher
Barts Cancer Institute
07.2016 - 09.2017
- Mentored junior researchers, enhancing their skills and supporting their career development.
- Overcame technical challenges by troubleshooting equipment issues or refining experimental procedures as necessary.
- Contributed to high-impact publications by collaborating with fellow researchers and providing critical input.
- Conducted thorough literature reviews to inform experimental design and maintain awareness of current trends in the field.
Research Associate
King's College London
06.2015 - 07.2016
- Monitored progress against project timelines, ensuring timely completion of deliverables while maintaining high-quality standards.
- Trained and mentored junior researchers, fostering a collaborative work environment that promoted knowledge sharing.
- Set up equipment, organized inventory and maintained facilities.
- Provided technical guidance on experimental design and data interpretation issues for team members as needed.
PhD Studentship
King's College London
06.2011 - 06.2015
- Presented research findings at national conferences, promoting knowledge sharing among fellow scholars.
- Implemented best practices in experimental design, optimizing study outcomes and minimizing errors.
- Prepared engaging presentations showcasing research findings to diverse audiences both within academia and beyond.
- Mentored undergraduate students in lab techniques and protocols, enhancing their educational experience and preparing them for future careers.
- Conducted comprehensive literature reviews to inform research direction and ensure relevance within the field.
Research Assistant
King's College London
09.2009 - 06.2011
- Organized research materials, maintaining a well-ordered workspace conducive to productivity.
- Attended seminars and symposiums to improve overall knowledge and understanding.
- Recorded experimental findings in laboratory notebook to analyze and interpret experimental findings.
- Collaborated with other researchers to develop successful research strategies.
- Monitored project timelines, ensuring timely completion of tasks while maintaining high-quality output.
Education
Ph.D. - Tumour Biology And Immunology
King's College London
London06.2015
Master of Science - Immunlogy of Infectious Disease
London School of Hygiene And Tropical Medicine
London09.2009
Bachelor of Science - Biological Science
King's College London
London06.2006
Skills
- Manuscript Preparation
- Reporting Requirements
- Assay development
- Specific research projects
- Scientific Writing
- Written and oral communication
- Collaborative Research
- Lab Management
- Project Management
- Research design
Technical Expertise
2D/3D cell culture
Assay design and optimisation
HTS-screening and automation
Robotic liquid handling
High-throughput microcopy
R-based data wrangling and analysis
Incucyte
Cell biological technique
PBMC isolation/culture
qPCR/PCR/RT-PCR
FACS
ELISA/plate based assays
In-vivo experiment design
Publications
In progress:
- A novel redox-metabolic vulnerability in therapy-induced senescence Hickman O, David Vicente, Clare Isacke, Linardopoulos S, Turner N. Submission pending patent application submission.
First author publications:
- Cathepsin-L and Transglutaminase Dependent Processing of ps20: A novel Mechanism for ps20 Regulation via ECM Cross-Linking. Hickman O, Kim S, Dasgupta P, Galustian C, Smith RA, Vyakarnam A. Biochemical and Biophysical Reports, Volume 7, September 2016, Pages 328–337
- Stromal expression of ps20 regulates growth suppression and apoptosis in prostate cancer cells in a COX-2-dependent manner. Hickman O, Smith RA, Dasgupta P, Rao SN, Nayak S, Sreenivasan S, Vyakarnam A, Galustian C. British Journal of Cancer. 2016 May 24; 114(11): 1235–1242.
Other:
- Under review (Nature Communication): Inhibition of GPX4 enhances CDK4/6 inhibitor activity in breast cancer. Herrera-Abreu M, Khalid, U, Ning J, Cutts R, Wilson G., Frankum J, Roumeliotis T, Hickman O, Brough, R, Choudhary J, Lord, C.J, Swain A, Turner, N.C.
- Under review (Rheumatology): Biomarkers confirm that resetting immune function underlies the efficacy of the novel biologic, IRL201805. Hall C, Pleasance J, Hickman O, Kirkham B, Eggleton P, Panayi G/S, Corrigall, V.
- Inhibition of Bromodomain Proteins Enhances Oncolytic HAdVC5 Replication and Efficacy in Pancreatic Ductal Adenocarcinoma (PDAC) Models. Tizong Miao, Alistair Symonds, Oliver J. Hickman, Dongsheng Wu, Ping Wang, Nick Lemoine, Yaohe Wang, Spiros Linardopoulos, Gunnel Halldén. Int. J. Mol. Sci. 2024, 25(2), 1265; https://doi.org/10.3390/ijms25021265
- Engineered niches support the development of human dendritic cells in humanized mice. Anselmi G, Vaivode K, Dutertre CA, Bourdely P, Missolo-Koussou Y, Newell E, Hickman O, Wood K, Saxena A, Helft J, Ginhoux F, Guermonprez P. Nat Commun. 2020 Apr 28;11(1):2054. doi: 10.1038/s41467-020-15937-y.
- Immunotherapy of prostate cancer: identification of new treatments and targets for therapy, and role of WAP domain-containing proteins. Galustian C, Vyakarnam A, Elhage O, Hickman O, Dasgupta P, Smith RA, Biochemical Society Transactions, 2011 Oct; 39(5):1433-6.
Timeline
Postdoctoral Fellow
Institute Of Cancer Research
10.2017 - Current
Postdoctoral Researcher
Barts Cancer Institute
07.2016 - 09.2017
Research Associate
King's College London
06.2015 - 07.2016
PhD Studentship
King's College London
06.2011 - 06.2015
Research Assistant
King's College London
09.2009 - 06.2011
Ph.D. - Tumour Biology And Immunology
King's College London
Master of Science - Immunlogy of Infectious Disease
London School of Hygiene And Tropical Medicine
Bachelor of Science - Biological Science
King's College London
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