Summary
Overview
Work history
Education
Skills
Custom
Personal Information
Languages
Accomplishments
Affiliations
References
Timeline
Generic

M. Julia Machline-Carrion

London,City of London

Summary

High-achieving senior academic and executive bringing expertise in high impact research leadership, strategic and business planning, and revenue development. Professional skilled in leading high-performing scientific teams. Offering over 10 years of leadership in large-scale clinical and epidemiological research along with entrepreneurial, forward-thinking mindset and demonstrated track record of accomplishment. Doctor Machline has served as the Chair of Steering Committee and Principal Investigator of international studies that were published in major medical journals. Innovative and driven with proven ability to lead projects and inspire teams, combined with strategic thinking and excellent communication skills. Adept in building partnerships and managing resources to drive operational efficiency. Ready to make significant impact in Medical Director role.

Overview

17
17
years of professional experience
2019
2019
years of post-secondary education

Work history

Head of Scientific and Medical Affairs

epHealth
London, United Kingdom
10.2019 - Current
  • Spearheaded strategic decisions that drove company's growth and expansion in clinical research and public health.
  • Developed new departments and technologies to advance research initiatives, aligning with corporate goals and global health priorities.
  • Established key public-private partnerships, collaborating with national and international healthcare authorities, pharmaceutical companies, and NGOs to support long-term business and research objectives.
  • Spearheaded the development of disease awareness projects in partnership with pharmaceutical companies, focusing on conditions such as vaccination, meningitis, dengue, Covid-19, breast cancer, and stroke. These initiatives increased public understanding and engagement with health interventions.
  • Supervised high-achieving team of over 30 professionals, providing orientation, training, and mentorship to foster culture of innovation and performance excellence.
  • Led multi-centre clinical trials involving over 100 collaborators, overseeing operations, timelines, and budgets to ensure compliance with clinical protocols and regulatory requirements.
  • Secured research grants and contracts with government agencies and pharmaceutical industry, leading to sustained project funding.
  • Coordinated with site staff, investigators, and regulatory agencies to ensure smooth progress of clinical trials, mitigating risks and ensuring data integrity.
  • Cultivated forward-thinking, inclusive and performance-orientated culture to lead innovation in designing efficient projects.
  • Directed staffing requirements, managed priorities and coordinated workflows to uphold productivity objectives.
  • Maintained smooth operations through careful management of office workflow and administrative processes.
  • Kept accurate records, upholding compliance with regulations and organisation policies.
  • Collaborated with cross-functional teams (including Translational Medicine, GMA, and Marketing) to align trial outcomes with strategic business needs.
  • Maintained up-to-date knowledge of emerging medical developments, clinical trials, and new drugs, applying this knowledge to optimise clinical trial designs
  • Evaluated clinical findings to make informed treatment decisions and foster positive patient outcomes.
  • Practised in accordance with internal guidelines, SOPs and clinical study protocols to mitigate risks.
  • Collaborated with cross-functional teams to ensure successful clinical trials.
  • Managed end-to-end value proposition creation for new product lines, driving innovation and alignment with technological strategies.
  • Helped with creation and implementation of new policies.
  • Utilised persuasive communication skills to overcome objections and secure projects deployments.

Co-founder

Instituto epHealth
Florianópolis, Brazil
12.2022 - Current
  • Within this not for profit organization, collaborated in generating projects tackling important public health concerns and providing access to populations most in need.
  • Guaranteed substantial 3.5 million dollars grant for applied public health projects directed to non-communicable diseases.


Clinical Trialist

Academic Research Organization, Hospital Israelita Albert Einstein
São Paulo, Brazil
12.2018 - 08.2019
  • Oversaw complex clinical trials, ensuring compliance with GCP guidelines and regulatory requirements.
  • Supervised budgets and resources, ensuring project delivery within scope and timelines.
  • Built productive relationships with governments, public funding agencies, and the pharmaceutical industry to advance clinical trial objectives.
  • Led clinical data review, contributing to the scientific assessment of trial results and regulatory submissions.
  • Provided leadership in the evaluation of clinical findings, making informed decisions to guide treatment strategies and ensure positive patient outcomes.
  • Published research findings in high-impact medical journals
  • Presented research findings with clear communication and data visualisation skills.
  • Shared group research at conventions, seminars and conferences as official presenter.
  • Selected, trained and performance-managed research.
  • Sourced research funding using expertise in grant and bid writing.
  • Disseminated research findings to relevant organisations and bodies.

Clinical Trialist

Research Institute HCor, Hospital do Coração
São Paulo, Brazil
01.2012 - 01.2018
  • Developed international research networks for deploying large scale clinical trials in cerebrovascular diseases.
  • Applied rigorous research methodology to manage from phase 1 to large-scale phase 3 clinical trials.
  • Collaborated into health technology assessment projects.
  • Provided evidence based medicine and research methodology training to medical residents.
  • Published research findings in high-impact medical journals .
  • Presented research findings with clear communication and data visualisation skills.
  • Shared group research at conventions, seminars and conferences as official presenter.
  • Selected, trained and performance-managed research.
  • Sourced research funding using expertise in grant and bid writing.
  • Disseminated research findings to relevant organisations and bodies.
  • Planned research activities to develop new processes, products and applications.
  • Evaluated research findings to provide key development insight.

Neurologist

Hospital Tacchini
Bento Gonçalves
01.2010 - 01.2012

Post-Graduate Student

Division of Neurology, Pontifícia Universidade Católica do Rio Grande Do Sul
Porto Alegre, Brazil
01.2008 - 01.2010
  • Acquired technical skills for developing phase 1 clinical trials.
  • Developed teaching skills for medical and scientific training.
  • Collaborated with multidisciplinary teams including molecular biologists, radiologists, pharmacists, radiologists.
  • Attended workshops and training sessions, enhancing practical skills relevant to coursework.
  • Liaised with relevant parties using appropriate communication channels.

Education

Ph.D - Translational Medicine

Universidade Federal de São Paulo

Certificate of Higher Education - Clinical Research

Duke/NIH Clinical Research Training Program
08.2013 - 08.2015

M.H.S - Neurosciences

Pontifícia Universidade Católica do Rio Grande do Sul

Fellowship - Neurology

Pontifícia Universidade Católica do Rio Grande do Sul

M.D - Medicine

Universidade Federal de Ciências da Saúde de Porto Alegre

Skills

  • Clinical Development Strategy
  • Clinical Program Management and Coordination
  • Clinical leadership and strategic medical input
  • Global Collaboration and Leadership
  • Medical and scientific data review
  • Safety Reporting and Documentation Support
  • Therapeutic area support
  • Regulatory and Stakeholder Communication
  • Translational Medical Sciences Collaboration
  • On-boarding and training processes participation
  • Medical and scientific training contributio
  • Global Initiative Leadership and Participation
  • Calm under pressure
  • Communication skills

Custom

  • Statins use for primary prevention of cardiovascular disease: A population-based digitally enabled real-world evidence cross-sectional study in primary care in Brazil, Karla Santo, Raul D. Santo, Alysson Nathan Girotto, Josue Nieri, Frederico Monfardini, Priscila Raupp, Pedro Marton Pereira, Otavio Berwanger, M Julia Machline-Carrion, J Clin Lipidol, 05/2024, 10.1016/j.jacl.2024.02.005
  • Assessing statins use in a real-world primary care digital strategy: a cross-sectional analysis of a population-wide digital health approach, M Julia Machline-Carrion, Alysson Nathan Girotto, Josué Nieri, Pedro Marton Pereira, Frederico Monfardini, Francisco Forestiero, Priscila Raupp, Fabiana Roveda, Karla Santo, Otavio Berwanger, Raul D Santos, Lancet Reg Health Am, 06/2023, 10.1016/j.lana.2023.100534
  • Digital Health-Enabled Clinical Trials in Stroke: Ready for Prime Time?, Otavio Berwanger, M Julia Machline-Carrion, Stroke, 09/2022, 10.1161/STROKEAHA.122.037378
  • Prevalence, characteristics, and predictors of early termination of cardiovascular clinical trials due to low recruitment: insights from the ClinicalTrials.gov registry, Sabrina Benardez-Pereira, Renato D Lopes, M. Julia Machline Carrion, Eliana Vieira Santucci, Rafael Marques Soares, Matheus de Oliveira Abreu, Ligia Nasi Laranjeira, Dimas T Ikeoka, Ana Denise Zazula, Frederico Rafael Moreira, Alexandre Biasi Cavalcanti, Evandro Tinoco Mesquita, Eric D Peterson, Robert M Califf, Otavio Berwanger, Methodological Evaluation of clinical TriAls Study Group, Am Heart J, 08/2014, 10.1016/j.ahj.2014.04.013

Personal Information

Title: Head of Medical Affairs

Languages

English
Proficient (C2)
Portuguese
Native
French
Upper intermediate (B2)
Spanish
Elementary (A2)

Accomplishments

List of Selected Publications:


Lancet Reg Health Am. 2023 Jun 22:23:100534.doi: 10.1016/j.lana.2023.100534. eCollection 2023 Jul. Assessing statins use in a real-world primary care digital strategy: a cross-sectional analysis of a population-wide digital health approach

M Julia Machline-Carrion , Alysson Nathan Girotto , Josué Nieri , Pedro Marton Pereira , Frederico Monfardini , Francisco Forestiero , Priscila Raupp , Fabiana Roveda , Karla Santo , Otávio Berwanger , Raul D Santos


J Clin Lipidol. 2024 May-Jun;18(3):e384-e393. doi: 10.1016/j.jacl.2024.02.005. Epub 2024 Feb 20. Statins use for primary prevention of cardiovascular disease: A population-based digitally enabled real-world evidence cross-sectional study in primary care in Brazil. Karla Santo, Raul D. Santo, Alysson Nathan Girotto , Josue Nieri , Frederico Monfardini , Priscila Raupp , Pedro Marton Pereira , Otavio Berwanger , M Julia Machline-Carrion


Stroke. 2022 Sep;53(9):2967-2975. doi: 10.1161/STROKEAHA.122.037378. Epub 2022 Jun 30. Digital Health-Enabled Clinical Trials in Stroke: Ready for Prime Time? Otavio Berwanger, M Julia Machline-Carrion


Machline-Carrion, M. Julia ; Santucci, Eliana Vieira; Damiani, Lucas Petri; Bahit, M. Cecilia; Málaga, Germán; Pontes-Neto, Octávio Marques; Martins, Sheila Cristina Ouriques; Zétola, Viviane Flumignan; Normilio-Silva, Karina; Rodrigues de Freitas, Gabriel; Gorgulho, Alessandra; de Salles, Antônio; Pacheco da Silva, Beatriz Gonzales; Santos, Juliana Yamashita; De Andrade Jesuíno, Isabella; Bueno, Priscila Regina Torres; Cavalcanti, Alexandre Biasi; Guimarães, Hélio Penna; Xian, Ying; Bettger, Janet Prvu; Lopes, Renato D ; Peterson, Eric D ; Berwanger, Otávio . Effect of a Quality Improvement Intervention on Adherence to Therapies for Patients with Acute Ischemic Stroke and Transient Ischemic Attack: A Cluster Randomized Clinical Trial. JAMA neurology 2019; 76 (8):932-41


Machline-Carrion, Maria Julia ; Santucci, Eliana Vieira; Damiani, Lucas Petri; Bahit, Cecilia; Málaga, Germán; Ponte-Neto, Octávio Marques; Martins, Sheila Cristina Ouriques; Zétola, Viviane Flumignan; Normilio-Silva, Karina; De Freitas, Gabriel Rodrigues; Gorgulho, Alessandra; De Salles, Antônio; Da Silva, Beatriz Gonzales Pacheco; Santos, Juliana Yamashita; De Andrade Jesuíno, Isabella; Bueno, Priscila Regina Torres; Cavalcanti, Alexandre Biasi; Guimarães, Hélio Penna; Xian, Ying; Bettger, Janet Prvu; Lopes, Renato D.; Peterson, Eric D.; Berwanger, Otávio. An international cluster-randomized quality improvement trial to increase the adherence to evidence-based therapies for acute ischemic stroke and transient ischemic attack patients: Rationale and design of the BRIDGE STROKE Trial. Am Heart J 2019; 207 :49-57


Am Heart J. 2014 Aug;168(2):213-9.e1.doi: 10.1016/j.ahj.2014.04.013. Epub 2014 May 2. Prevalence, characteristics, and predictors of early termination of cardiovascular clinical trials due to low recruitment: insights from the ClinicalTrials.gov registry Sabrina Benardez-Pereira, Renato D Lopes , M. Julia Machline Carrion , Eliana Vieira Santucci , Rafael Marques Soares , Matheus de Oliveira Abreu , Ligia Nasi Laranjeira , Dimas T Ikeoka , Ana Denise Zazula , Frederico Rafael Moreira , Alexandre Biasi Cavalcanti , Evandro Tinoco Mesquita , Eric D Peterson , Robert M Califf , Otavio Berwanger ; Methodological Evaluation of clinical TriAls Study Group



Affiliations

  • Collecting First Editions.
  • Pilates
  • Travelling

References

References available upon request.

Timeline

Co-founder

Instituto epHealth
12.2022 - Current

Head of Scientific and Medical Affairs

epHealth
10.2019 - Current

Clinical Trialist

Academic Research Organization, Hospital Israelita Albert Einstein
12.2018 - 08.2019

Certificate of Higher Education - Clinical Research

Duke/NIH Clinical Research Training Program
08.2013 - 08.2015

Clinical Trialist

Research Institute HCor, Hospital do Coração
01.2012 - 01.2018

Neurologist

Hospital Tacchini
01.2010 - 01.2012

Post-Graduate Student

Division of Neurology, Pontifícia Universidade Católica do Rio Grande Do Sul
01.2008 - 01.2010

M.H.S - Neurosciences

Pontifícia Universidade Católica do Rio Grande do Sul

Fellowship - Neurology

Pontifícia Universidade Católica do Rio Grande do Sul

M.D - Medicine

Universidade Federal de Ciências da Saúde de Porto Alegre

Ph.D - Translational Medicine

Universidade Federal de São Paulo

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M. Julia Machline-Carrion