Pyhton
Matthew Shipley
PhD Student
London
Summary
First year PhD student with a passion for translational research and currently utilizing a range of bioinformatics and molecular biology skills at the Institute of Cancer Research to pioneer therapeutic strategies for ATRX mutated neuroblastoma. Demonstrated expertise in multiomic approaches and a collaborative spirit, significantly advancing understanding of high-risk neuroblastoma biology.
Overview
3
3
years of professional experience
1
1
Certification
Work History
PhD Student
Institute Of Cancer Research
10.2024 - Current
- Started my PhD project with the aim to identify novel therapeutic approaches targeting DNA damage repair pathways in ATRX mutated neuroblastoma.
- Overall goal of project is to identify specific dependencies in ATRX mutated cancers in the context of DNA damage using a range of range of multiomic approaches.
Scientific Officer
Institute Of Cancer Research
11.2023 - 10.2024
- Undertook the position of scientific officer in Dr Sally George's Developmental Oncology lab in the clinical studies division focusing on high-risk neuroblastoma research to further understand tumour biology to aid in the development of new therapies and treatment biomarkers
- Gained experience in cell culture, siRNA and shRNA, CRISPR Cas9, plasmid generation, drug combination studies, western blotting, Immunofluorescence, confocal imagining, maintaining detailed records of experiments and adhering to established guidelines.
- Assisted other researchers with their projects as well as undertook my own research.
- Represented the lab at a variety of different conferences in neuroblastoma and childhood cancers.
- Presented research findings at meeting and seminars.
Masters Research Student
Cancer Research UK Scotland Institute
05.2023 - 09.2023
- Undertook a 4 month research project in Professor Jen Morton's Lab which involved testing the efficacy of an ATR inhibitor and MEK inhibitor in pancreatic cancer cells lines with defects in DDR pathways to find potential new therapies.
- Gained experience in key molecular biology techniques such as cell culture, western blotting, clongoenic assay and drug combination studies.
- Maintained meticulous records of research activities, ensuring accuracy and compliance with ethical guidelines.
- Gained experience as an independent researcher planning experiments to meet my own hypotheses.
Undergraduate Research Student
University of Edinburgh
01.2022 - 05.2022
- Undertook a research project that involved an analysis of different neuronal populations within the postsubiculum of a rat model of Fragile X syndrome.
- Gained extensive experience in working with animal models including animal handling and preforming experiments.
- Utilized advanced statistical software (Prism, FIJI, R studio, MATLAB) to conduct thorough data analyses.
- Improved overall lab safety by implementing proper procedures while handling chemicals or hazardous materials during experiments.
- Presented findings to other group members, showcasing the value of undergraduate research contributions.
Education
Master of Science - Cancer Research And Precision Oncology
University of Glasgow
Glasgow, United Kingdom 04.2001 -
Bachelor of Science - Neuroscience
The University of Edinburgh
Edinburgh, United Kingdom 04.2001 -
Skills
Molecular Biology
Bioinformatics
Research and Analysis
Translational Research
Software
R Studio
Perseus
Prism
SPSS
Certification
Rodent Home Office Personal Licence: PIL ABK
Timeline
PhD Student
Institute Of Cancer Research
10.2024 - Current
Scientific Officer
Institute Of Cancer Research
11.2023 - 10.2024
Masters Research Student
Cancer Research UK Scotland Institute
05.2023 - 09.2023
Undergraduate Research Student
University of Edinburgh
01.2022 - 05.2022
Rodent Home Office Personal Licence: PIL ABK
11-2021
Master of Science - Cancer Research And Precision Oncology
University of Glasgow
04.2001 -
Bachelor of Science - Neuroscience
The University of Edinburgh
04.2001 -
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