Summary
Overview
Work history
Education
Skills
Accomplishments
Certification
Additional Information
Timeline
Generic
LINOS LAZARIDES

LINOS LAZARIDES

Oakwood,US

Summary

I am an enthusiastic organic/medicinal chemist with strong theoretical and practical skills. I have made positive and intuitive contributions to help drive two lead optimization programmes towards candidate selection. I am a diligent and highly organized individual achieving targets in timely fashion. Excellent communication skills have resulted in effective representation of programme work at matrix meetings and internal/external conferences. A strong team player, building strong rapport with members and sharing knowledge and experience. Burgeoning medicinal chemistry and supervisory skills .

Overview

21
21
years of professional experience
1
1
Certification

Work history

01.1999
  • Project Title: The synthesis of DOTMA and analogues for use in gene transfection.

MITSU LONDON
1 1

Senior Scientist

Selcia Ltd
08.2008 - Current

Senior Scientist

GlaxoSmithKline Medicines Research Centre, Infectious Diseases Centre of Excellence for Drug Discovery
04.2004 - 06.2008
  • Have demonstrated strong knowledge of synthetic and practical chemistry.
  • This has involved the implementation of neat synthetic tactics to synthesize multi-gram quantities of a number of unknown key intermediates.
  • This allowed formation of acylpyrrolidine targets for the HCV polymerase inhibitor programme, which permitted the acquisition of crucial biological data.
  • These targets were selected as backup-molecules to the candidate.
  • My highly productive work in this area culminated in co-inventorship on five patents.
  • Initiated the chemistry for a new start-up project.
  • Designed various synthetic routes, amenable to array chemistry allowing attainment of early targets to establish SAR.
  • Routes were subsequently used by project group/external collaborators and were central to the progression of the programme towards candidate selection.
  • Played a key role in large scale synthesis (50g) of important targets.
  • This work has resulted in co-inventorship on 3 patents and also me being awarded an R&D Recognition award.
  • For various programmes have made a number of pertinent suggestions towards new targets based on SAR and discussions with computer modellers.
  • This has allowed proactive synthesis of new targets with high potency.
  • Utilized internal software packages to identify novel scaffolds of initial hit molecules and subsequently executed chemistry in pursuit of new lead series.
  • Experience of Spotfire to analyse patterns in various parameters of target molecules.
  • Management and overseer of the GSK HCV Protease database.
  • Effective presentations at meetings with external partners and active participation offering suggestions to synthetic problems encountered on different programmes.
  • Suggestions made allowed synthesis of first novel template for the HCV protease programme, which showed biochemical potency and was a major initial hurdle overcome.
  • Regular presentations at departmental/project meetings discussing SAR and PK.
  • Have attended the Medicinal Chemistry School, Nottingham (2005).
  • Effective supervision of two IP students, developing their practical/theoretical skills through exposure to a variety of chemistry and ensuring compliance with safety procedures.
  • Developed excellent rapport.
  • Currently overseer PhD case award student (Bath University).
  • Regular involvement in recruitment, acting as site host, conducting technical interviews and participation in panel discussions for the selection of successful candidates.
  • Received a GSK Recognition award for effective supervision.
  • Member of postgraduate internal tutor's panel, supporting the continuous organic chemistry education of graduate employees.
  • Profile enhanced significantly by presentation of HCV Polymerase poster at 31st ACS Medicinal Chemistry Symposium, Pittsburgh (2008), poster at GSK Medicinal Chemistry conference, Verona (2007) and Acylpyrrolidine talk at GSK Medicinal Chemistry symposium, Stevenage (2005).
  • June-July Summer Organic Chemistry Studentship, UCL.

01.2008 - 06.2007
  • Organized and created an electronic database of >25,000 stock items, prepared and coordinated despatchments for distribution worldwide, team leader coordinating work of others.

Education

Analogs with Potent Anticancer and β-Catenin/TCF4/Osteopontin Inhibitory Effects and Insights Into How A83586C Modulates E2Fs and pRb; K J Hale, S Manaviazar, L Lazarides, J George, M A Walters, J Cai, V Delisser, G S Bhatia, S A Peak, S M Dalby, A Lefranc, Y P Chen, A W Wood, P Crowe, P Erwin, M El-Tanani; Organic Letters - undefined

2009

Vol 11, No 3, 737-740 O-Directed Free-Radical Hydrostannations of Propargyl Ethers, Acetals, and Alcohols with Ph3SnH and Et3B; P Dimopoulos, A Athlan, S Manaviazar, J George, M Walters, L Lazarides, A Aliev, K J Hale; Organic Letters - undefined

2005

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University College London

Vol 7, No 24 - undefined

Synthesis Of An L
2002

PhD - undefined

University College London

MSci - Medicinal Chemistry

University College London

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Southgate Secondary School

Skills

  • Computer Software: Word, Excel, Powerpoint, Lotus Notes, Electronic LabNotebook, CrossFire, SciFinder, Spotfire
  • Backup
  • Basic
  • C
  • Database
  • Electronic Commerce
  • Erwin
  • First Aid
  • IP
  • Team leader
  • Letters
  • Lotus Notes
  • Mathematics
  • Meetings
  • Excel
  • Powerpoint
  • Win
  • 98
  • Word
  • Neat
  • Novel
  • Peak
  • PhD
  • Presentations
  • PUBLICATIONS
  • Publication
  • Rapport
  • Recruitment
  • Research
  • Safety
  • Sales
  • Selling
  • Strategy
  • Supervisory
  • Supervision
  • Symposium

Accomplishments

  • 7,9-Dihydro-8H-purin-8-one derivatives as human interferon inducers and their preparation, pharmaceutical compositions and use in the treatment of allergy and inflammation; Bazin-Lee, Helene; Coe, Diane Mary; Lazarides, Linos; Mitchell, Charlotte Jane; Smith, Stephen Allan; Trivedi, Naimisha; WO, Synthesis and evaluation of novel a-amino cyclic boronates as inhibitors of HCV NS3 protease; Xianfeng Li, Yong-Kang Zhang, Yang Liu, Charles Z.Ding, Qun Li, Yasheen Zhou, Jacob J.Plattner, Stephen J.Baker, Xuelei Gian, Dazhong Fan, Liang Liao, Zhi-Jie Ni, Gemma V.White, Jackie E.Mordaunt, Linos Lazarides, Martin J.Slater, Ricahrd L.Jarvest, Pia Thommes, Malcolm Ellis, Colin M.Edge, Julia A.Hubbard, Don Somers, Paul Rowland, Pamlea Nassau, Bill McDowell, Tadeusz J.Skarzynski, Wieslaw M.Kazmierski, Ricahrd M.Grimes, Lois L.Wright, Gary K.Smith, Wuxin Zou, Jon Wright, Lewis E.Pennicott; Bioorganic & Medicinal Chemistry Letters, 2010, Vol 20(12), 3550-3556Novel Adenine Derivatives; Helene Bazin-Lee, Diane M Coe, Linos Lazarides, Charlotte J Mitchell, Stephen A Smith, Naimisha Trivedi; WO 2010018134Preparation of novel cyclic boronate inhibitors of HCV replication; Fan, Dazhong; Jarvest, Richard Lewis; Lazarides, Linos; Li, Qun; Li, Xianfeng; Liu, Yang; Liao, Liang; Mordaunt, Jacqueline Elizabeth; Ni, Zhi-Jie; Plattner, Jacob; Qian, Xuelei; Slater, Martin John; White, Gemma Victoria; Zhang, Yong Kang; WO 2009046098 A1 Preparation of purine derivatives as immunomodulators; Lazarides, Linos; Smith, Stephen Allan; Stocker, Richard; Theobald, Colin Jack; WO 2008101867 A1C (2)-Heteroarylmethyl-C (4)-Pyrazinyl-2-yl.

Certification

Synthetic Route To The GE3 Cyclodepsipeptide; Karl J.Hale, Linos Lazarides; Organic Letters, 2002, Vol 4, No 11, 1903-1906 A Synthetic Strategy For The Cyclodepsipeptide Core Of The Antitumor Antibiotic Verucopeptin; Karl J.Hale, Linos Lazarides, Jiaqiang Cai; Organic Letters, 2001, Vol.3, No.18, 2927-2930 ACADEMIC PRIZES 2008 GSK R&D Recognition award for effective supervision of South African undergraduates on the GSK residential course, First Aid At Work ‘Selling To Win' Sales Skill (Richard Denny (April 2014)

Additional Information

  • 2007 GSK R&D Recognition award for excellence displayed in chemistry. 2002 Waterstones Excellence and Achievement Award 2000/03 AVERT Postgraduate Studentship 2000/01 Tuffnell Scholarship 1999/00 Parke-Davies Prize, Alfred Bader Prize, Franz Sondheimer Prize for distinguished work in Organic Chemistry 1999/00 SmithKline Beecham Bursary Award for Promising Young Scientist 1998/99 UCL Departmental Prize 1997/98 UCL Departmental Prize, UCL Faculty Award for top student within the Maths and Physical Sciences Faculty, Pfizer Award for Practical Chemistry 1996/97 UCL Departmental Prize for top student within the department 1996 UCL Departmental Scholarship 1995/96 Pater Prize for outstanding academic achievement (A-Levels)

Timeline

Senior Scientist

Selcia Ltd
08.2008 - Current

01.2008 - 06.2007

Senior Scientist

GlaxoSmithKline Medicines Research Centre, Infectious Diseases Centre of Excellence for Drug Discovery
04.2004 - 06.2008

01.1999

Analogs with Potent Anticancer and β-Catenin/TCF4/Osteopontin Inhibitory Effects and Insights Into How A83586C Modulates E2Fs and pRb; K J Hale, S Manaviazar, L Lazarides, J George, M A Walters, J Cai, V Delisser, G S Bhatia, S A Peak, S M Dalby, A Lefranc, Y P Chen, A W Wood, P Crowe, P Erwin, M El-Tanani; Organic Letters - undefined

Vol 11, No 3, 737-740 O-Directed Free-Radical Hydrostannations of Propargyl Ethers, Acetals, and Alcohols with Ph3SnH and Et3B; P Dimopoulos, A Athlan, S Manaviazar, J George, M Walters, L Lazarides, A Aliev, K J Hale; Organic Letters - undefined

undefined

University College London

Vol 7, No 24 - undefined

Synthesis Of An L

PhD - undefined

University College London

MSci - Medicinal Chemistry

University College London

undefined

Southgate Secondary School

MITSU LONDON
1 1

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LINOS LAZARIDES