Jiaxin Fang
Leicester,Leicestershire
Overview
5
5
years of professional experience
Work history
PhD Phase
Kogularamanan Suntharalingam
02.2022 - 01.2026
Our group focused on synthesizing inorganic metal drugs for targeting cancer stem cells and I've been mainly working with cobalt(III) complexes anti-breast cancer stem cells. The cobalt(III) complexes were synthesized and fully characterized by NMR, MS, IR, elemental analysis and X-ray crystal structure. The pure cobalt(III) complexes would be monitored stability via UV-vis, MS or NMR then further tested toxicity and mechanism of cell death in vitro using biological techniques including MTT assay, microscope, flow cytometry and western blot. Promising complexes would be continued for in vivo study.
Bachelor Phase
Xuezhi Song
09.2020 - 07.2021
We developed a catalyst containing different ratios of bismuth(Bi) and cerium(Ce) for catalysing nitrogen reduction.
Education
Bachelor of Science - Chemical Engineering
Dalian University of Technology
Liaoning, China 09.2017 - 07.2021
Doctor of Philosophy - Bio-inorganic Chemistry
University of Leicester
Leicester 02.2022 -
Skills
- Inorganic and organic chemistry synthesis
- Western blot
- Flow cytometry
- Microscope operating
- Data analysis with MestreNova, ChemDraw, Origin and ImageJ
- Paper writing
Languages
Chinese (Mandarin)
Native
English
Intermediate (B1)
Publications
[1] J. Fang, O. N. Orobator, C. Olelewe, G. Passeri, K. Singh, S. G. Awuah and K. Suntharalingam, A Breast Cancer Stem Active Cobalt(III)-Cyclam Complex Containing Flufenamic Acid with Immunogenic Potential. Angew. Chem. Int. Ed. 2024, 63, e202317940.
[2] J. Fang, P. Gerschel, K. Singh, U.-P. Apfel and K. Suntharalingam, Cobalt(III)–Macrocyclic Scaffolds with Anti-Cancer Stem Cell Activity. Molecules. 2024, 29, 2743.
[3] J. Fang, K. Singh and K. Suntharalingam, Anti-Cancer Stem Cell Cobalt(III)-Polypyridyl Complexes Containing Salicylic Acid. Inorganics. 2024, 12, 202.
[4] J. Fang*, Y. Li*, K. Singh, F. Ortu and K. Suntharalingam, An Immunogenic Anti-Cancer Stem Cell Bi-nuclear Copper(ii)-Flufenamic Acid Complex. Dalton Transactions, 2024, 53, 6410-6415. (*: equal contribution)
[5] P. B. Osei, J. Northcote-Smith, J. Fang, K. Singh, F. Ortu and K. Suntharalingam, The Bulk Breast Cancer Cell and Breast Cancer Stem Cell Activity of Binuclear Copper(II)-Phenanthroline Complexes. Chemistry – A European Journal, 2023, 29, e202301188.
Timeline
PhD Phase
Kogularamanan Suntharalingam
02.2022 - 01.2026
Doctor of Philosophy - Bio-inorganic Chemistry
University of Leicester
02.2022 -
Bachelor Phase
Xuezhi Song
09.2020 - 07.2021
Bachelor of Science - Chemical Engineering
Dalian University of Technology
09.2017 - 07.2021
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