HADIL SALEH

PhD-trained cancer biologist with expertise in investigating treatment response and resistance mechanisms using CRISPR-Cas9, qPCR, and molecular cloning. Experienced in applying a range of cellular and molecular techniques, including immunofluorescence, western blotting, and functional assays, to study pathway-driven responses in cancer models. My work has developed a strong focus on the molecular basis of therapeutic resistance, which I am keen to apply to antimicrobial drug resistance, particularly in mapping resistance pathways and identifying strategies to overcome them

• Saleh H, Liloglou T, Rigden DJ, Parsons JL, Grundy GJ. KH-like domains in PARP9/DTX3L and PARP14 coordinate protein–protein interactions to promote cancer cell survival. J Mol Biol. 2024;436(5):168434.
• Saleh H, Moore CM, Tzouveleki K, Dey M, Talbot G, Glenn M, Parsons JL, Grundy GJ. PARP9/DTX3L promotes homologous recombination and ATR activation during replication stress. Commun Biol. Under review, 2025.

• Saleh H, Liloglou T, Parsons JL, Grundy GJ. PARP14 promotes the survival of head and neck squamous cell carcinoma cell lines. Poster presentation, Liverpool Cancer Research Institute Symposium, 2021. Best Poster Award
• Saleh H, Liloglou T, Parsons JL, Grundy GJ. Exploring DNA repair roles of PARP9/DTX3L and PARP14 in cancer. Poster & flash talk, PARP 2023 Conference, Hvar, Croatia
• Saleh H, Liloglou T, Parsons JL, Grundy GJ. MacroPARP proteins PARP9 and PARP14 in HNSCC. Poster, BACR Annual Conference, Manchester, UK, 2023
• Saleh H, Liloglou T, Parsons JL, Grundy GJ. PARP9/DTX3L and PARP14 regulate cancer cell survival. Poster, Northwest Cancer Research Symposium, Lancaster, UK, 2023
• Saleh H, Liloglou T, Parsons JL, Grundy GJ. MacroPARP proteins as radiosensitizers in HNSCC. Poster, CRUK RadNet Conference, London, UK, 2022

• Grant recipient, Foundation for Women Graduates, Travel bursary to attend the CRISPR gene screening workshop at the Francis CRICK institute, London
• Best mature student, School of Life Sciences, University of Liverpool, 2019
• Best student in Biological and Medical Sciences, University of Liverpool, 2019
• Multiple early academic prizes, Best A level chemistry student (2014), Merseyside Young Analyst competition representative (2013), Top student award in Jeddah for highest overall average (2009)

• Dr Gabrielle Grundy, Department of Molecular and Clinical Cancer Medicine, University of Liverpool, +44 7548315831, Gabrielle.Grundy@liverpool.ac.uk
• Professor Jason Parsons, Institute of Cancer and Genomic Sciences, University of Birmingham, +44 (0) 1214146850, j.parsons.3@bham.ac.uk