Gianna Toschi
Buxton,Great Britain
Summary
Accomplished professional with expertise in medicinal chemistry and organic synthetic chemistry, specialising in oncology drug discovery. Proven track record as a project manager in multidisciplinary projects, effectively leading teams to achieve strategic objectives. Experienced line manager and laboratory manager, committed to advancing innovative solutions in the pharmaceutical industry.
Overview
20
20
years of professional experience
11
11
years of post-secondary education
Work history
Associate principal chemistry
Sygnature discovery
09.2019 - 05.2025
- Led multiple multidisciplinary projects with big pharma or biotech companies, in different areas of expertise (e.g. kinase inhibitors, GPCR antagonists and molecular glues and most recently payloads optimisation for ADCs) with particular focus for the treatment of oncological diseases.
- As medicinal chemistry project leader I have driven multi-parameter optimization on several chemical series demonstrating creativity, problem-solving and critical thinking skills to overcome several challenges all while building/strengthening IP (inventor in 7 patent family).
- As chemist I have implemented and optimized innovative synthetic routes and methodologies, resulting in a significant reduction in synthesis time and costs, and improving overall efficiency of compound synthesis while ensured that appropriate safety, health & environment (SHE) practices are followed.
- Collaborated with cross-functional teams to design and execute a comprehensive screening strategy, evaluating the pharmacokinetic properties and safety profiles of lead compounds, leading to selection of a preclinical candidates for further evaluation some of which were further advanced to become clinical candidates by different clients.
- Present medicinal chemistry strategy at corporate meetings
- I am inventor in 7 patent and authors of 9 articles.
Senior Chemist
Concept Life Sciences (formerly Peakdale Molecular Ltd)
11.2009 - 09.2019
- I have worked on drug discovery projects in multiple therapeutic areas for a number of major pharmaceutical companies.
- I have been involved in both the design and synthesis of small-molecule drug candidates, sometimes by complex and novel routes.
Post-doctoral Fellowship
CSIR (Centre of Scientific and Industrial Research) South Africa
01.2007 - 01.2008
Post-doctoral Fellowship
Claude Leon Foundation
01.2005 - 06.2007
Education
PhD - Chemistry
University of Wales
Bangor, Gwynedd 10.2000 - 11.2004
Laurea - Chimica
University of Trieste
11.1993 - 07.2000
Skills
Medicinal chemistry
Organic synthetic chemistry
Project manager in multidisciplinary project
Line manager
Laboratory manager
Drug discovery
Optimization of ADMET parameters
Nationality
Italian (resident in Great Britain for more than 20 years, with the right to work in UK)
Affiliations
- Drug discovery enthusiast, Architecture and Art, Tennis.
References
References available upon request.
Timeline
Associate principal chemistry
Sygnature discovery
09.2019 - 05.2025
Senior Chemist
Concept Life Sciences (formerly Peakdale Molecular Ltd)
11.2009 - 09.2019
Post-doctoral Fellowship
CSIR (Centre of Scientific and Industrial Research) South Africa
01.2007 - 01.2008
Post-doctoral Fellowship
Claude Leon Foundation
01.2005 - 06.2007
PhD - Chemistry
University of Wales
10.2000 - 11.2004
Laurea - Chimica
University of Trieste
11.1993 - 07.2000
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