Clementino Ibeas Bih
London
Summary
Experienced cell biologist with a PhD in Pharmacy and a MSc in Neuroscience, Pharmacology, and Physiology. Combines expertise in molecular biology, neurobiology, and drug discovery with strong programming and data analytics skills. Over a decade of experience across various stages of the drug discovery pipeline, proficient in R, C++, Bash, SQL, and Python. Skilled in preprocessing and analysing diverse biological data sets, including omics, imaging, electrophysiology and high-throughput screening data. Demonstrated success in platform development, capability building, and contributing to comprehensive evaluations that enhance decision-making in drug discovery.
Overview
10
10
years of professional experience
Work History
Senior Scientist
GSK
11.2021 - 02.2024
- Led the development of in vitro cell assays using immortalised and primary cells in 2D and 3D cultures for Parkinson's Disease and Polycystic Ovary Syndrome drug discovery. Developed biochemical assays using immunoassays like Peggy Sue and WES.
- Identified and validated disease biomarkers in Parkinson's Disease.
- Mapped Osteoarthritis signalling pathways using omics data integrated with knowledge graphs, machine learning, and NLP.
- Designed experiments to elucidate drug mechanisms on ion channels and extracellular matrix proteins.
- Conducted compound series selection and characterised pharmacological properties, including affinity and site of action.
- Developed algorithms for processing complex datasets (omics, imaging, electrophysiology). Engineered algorithms in R and C++ for high-content image analysis and automated neuronal firing detection. Automated analytical processes.
- Served as the departmental representative for the electronic lab notebook (Signals). Ensured data integrity and compliance with cybersecurity standards.
- Guided and trained team members in lab safety, immunoassays, automated analytical processes and report writing.
- Collaborated with international multidisciplinary teams and external partners (e.g., CROs).
Presented data in departmental meetings and contributed to multiple project portfolios.
Prepared formal reports and presentations for stakeholders. - Awarded multiple prizes for departmental support and successful project completion.
Molecular Biologist
MeiraGTx
07.2019 - 06.2021
- Played a pivotal role in establishing the Molecular Biology team
- Contributed in establishing a new liquid handling platform (TECAN) for automated ELISA screening of various AAV serotypes
- Developed cell lines with constitutive and conditional protein expression systems
- Performed molecular cloning - Designed and constructed plasmids to optimise recombinant AAV production (helper and packaging constructs and ShRNA expression constructs)
- Conducted transfections using plasmids, nanoplasmids, and doggybone DNA methods (PEI, Lipofectamine)
- Executed electroporation and viral transduction using lentivirus or AAV
- Validated plasmid sequences and maintained the plasmid database
- Authored reports and SOPs, ensuring compliance with data integrity standards
- Trained junior scientists in molecular biology techniques, including Western blot and qPCR.
Research Scientist
UCB Pharma
09.2018 - 02.2019
- Developed complex protein degradation assays for high-throughput screening using high-content imaging (Arrayscan) and proximity assays (FRET, Alpha-LISA)
- Established biotinylation-based methods for protein-protein interaction studies
- Created and optimised cell lines for assay purposes
- Generated and analysed concentration-response curves and conducted ligand-receptor interaction modelling and data analysis
- Prepared formal reports and presented findings to stakeholders
- Ensured data integrity through thorough review of data and notebooks
- Contributed to multiple large project portfolios
- Collaborated with international multidisciplinary teams (Belgium)
- Presented data in a matixed organisation and at departmental meetings.
PhD Research
University of Reading
06.2014 - 09.2018
- Developed assays to assess mitochondrial function and its impact on neuronal electrophysiological properties, integrating multiphoton microscopy, patch-clamp, and multi-electrode array techniques
- Identified the mechanism of action of a drug on mitochondrial function in epilepsy
- Created in vitro and in vivo disease models, including a chronic epilepsy rodent model induced by status epilepticus
- Contributed to the FDA approval of EPIDIOLEX for Lennox-Gastaut and Dravet syndromes
- Generated and analysed concentration-response curves
- Processed and analysed omics data and performed advanced analytical methods on existing datasets
- Served as a student demonstrator, teaching and training peers
- Trained team members in regulated procedures on small animals, ensuring compliance with project licenses
- Presented data at departmental meetings, conferences, and major university events
- Peer-reviewed scientific manuscripts.
Education
Data Science & Programming -
DataCamp
03.2025
PhD in Pharmacy -
University of Reading in Collaboration With GW Pharma
Reading, UK06.2019
MSc in Neuroscience, Pharmacology, and Physiology -
Université Claude-Bernard And Université De Lorraine
06.2013
Skills
- Drug Discovery - Target identification, validation, hit discovery, functional assay development, biomarker identification and validation, translational assay development, lead optimisation, and candidate selection
- Modalities - Small molecules, PROTACs, biologics (AAVs, antibodies)
- Disease areas - Epilepsy, Parkinson’s disease, Huntington's disease, Pain/Migraine, Polycystic Ovary Syndrome and Osteoarthritis Disease model development (in vitro & in vivo)
- Immunology - Antibody characterisation, cytokines screening, evaluation of neuroinflammation and compound screening on immune cells (microglia)
- Pharmacology - In vitro pharmacological studies, assay validation, concentration-response curves, IC₅₀/EC₅₀ determination, affinity studies Functional characterisation of molecules and ligand-receptor modelling
- Assay Development & Validation - Immunoassays, calcium assays, mitochondrial function assays, GPCR/ion channel/enzyme studies, ELISA, dot blot, Western blot, FRET assays, immunocytochemistry, and immunohistochemistry
- Electrophysiology - Whole-cell patch-clamp, sharp microelectrode, multi-electrode array (MEA) on brain tissues and immortalised cells
- Imaging & High-Throughput Screening - High-content imaging, FLIPR, flow cytometry, automated Western blot, multiphoton microscopy, confocal microscopy
- Genetics & Biochemistry (Molecular Biology) - PCR, qPCR, molecular cloning, gene knockdown, design shRNA, microarray, immunoprecipitation, sequencing, lipid fractionation (chromatography) and quantification, Mendelian/population genetics
- Cell Biology - Cell culture (2D/3D), transfection, electroporation, transduction, cell fractionation, transfection methods (PEI, Lipofectamine), creation of stable cell lines
- Computational Biology & Bioinformatics - RNA-seq, Affymetrix, GWAS, Data preprocessing, quality control, statistical analysis, modelling, pathway interpretation, and use of machine learning (Keras, TORCH, random forest, SVM)
- Programming & Data Analytics - Languages: R, C, Bash, Python, SQL Data preprocessing, biostatistics (multivariate statistics, regression, classification), machine learning, simulation (Monte Carlo), data visualisation (2D/3D in R), automation
- Application Development - Shiny apps, game development (Raylib)
- Object-Oriented Programming - S3, S4, R6 in R and C
- Software Proficiency - Spotfire, ImageJ (FIJI), Tecan-evoware, Image Studio Lite, Prism, GIMP, Inkscape, SnapGene
- Scientific Communication - Report writing, SOP creation, publication writing, presenting data in meetings and conferences
- Animal Behavioural Testing - Seizure scoring, Y-maze, open field, elevated plus maze
- Soft Skills - Project management, team leadership, training and mentoring, collaboration with international teams and working in a matrixed organisation
Timeline
Senior Scientist
GSK
11.2021 - 02.2024
Molecular Biologist
MeiraGTx
07.2019 - 06.2021
Research Scientist
UCB Pharma
09.2018 - 02.2019
PhD Research
University of Reading
06.2014 - 09.2018
Data Science & Programming -
DataCamp
PhD in Pharmacy -
University of Reading in Collaboration With GW Pharma
MSc in Neuroscience, Pharmacology, and Physiology -
Université Claude-Bernard And Université De Lorraine
Similar Profiles
Clotilde JoretClotilde Joret
Human Resources Business Partner at GSKHuman Resources Business Partner at GSK
RAHUL PANDEYRAHUL PANDEY
Area Business Manager at GSKArea Business Manager at GSK
Helena MangualHelena Mangual
Senior Biopharmaceutical Associate at GSKSenior Biopharmaceutical Associate at GSK
Sunil Kumar SSunil Kumar S
Associate Director SAP Basis at GSKAssociate Director SAP Basis at GSK
Mohammed Zia ShaheenMohammed Zia Shaheen
Founder & Principal Consultant at Loop Media-Social Media AgencyFounder & Principal Consultant at Loop Media-Social Media Agency