CAMILA BARBOSA
Abingdon,Oxfordshire
Summary
Accomplished professional with expertise in antigen discovery and TCR workflows, specialising in immunopeptidomics to guide antigen selection. Proficient in functional pharmacology, including T-cell activation and cytotoxicity assays, with a strong focus on mechanism of action studies and combination screening. Skilled in multi-colour flow cytometry and various readouts such as ELISA and multiplex cytokines, ensuring robust quality control. Experienced in genetic modification techniques, particularly lentiviral transduction of primary human T cells. Adept at preclinical decision support, providing comprehensive data packages and programme recommendations. Demonstrates leadership through cross-functional collaboration, training initiatives, and the introduction of innovative techniques to enhance research workflows.
Overview
10
10
years of professional experience
9
9
years of post-secondary education
Work history
Senior Research Associate
Evotec UK Ltd
2022.10 - 2026.03
- Designed and executed multi-parameter flow and cytokine assays to profile bispecific T-cell engagers, generating decision-ready data packages that informed programme go/no-go across the discovery–preclinical continuum.
- Optimised up to 5-laser flow panels (activation/exhaustion) and tightened QC/controls, improving assay robustness and inter-run reproducibility.
- Established multiplex cytokine panels with external vendors, harmonising calibration and controls across sites to reduce variability and enable cross-study comparability.
- Delivered GLP-compliant immunoassays (ELISA, MSD, ELISpot, CBA) with robust documentation; authored SOPs and assay reports.
- Mentored junior scientists in troubleshooting and QC review; introduced panel design and control strategies to improve preclinical workflow robustness.
Postdoctoral Researcher (T-Cell Immunology)
The Francis Crick Institute / King's College London
2021.01 - 2022.01
- Engineered antigen-specific T-cell introducing genetic modification into cell lines and/or primary human immune cells.
- Implemented an end-to-end immunopeptidomics pipeline (peptide purification → MS data interpretation) to inform antigen selection for TCR-based programmes, translating findings into functional assays.
- Isolated and cultured primary human immune cells; delivered proliferation, cytokine and flow datasets supporting translational oncology hypotheses.
- Genetically modified cell lines and primary immune cells (lentiviral transduction) to build GM in vitro models addressing mechanism-focused questions.
PhD Researcher
Oswaldo Cruz Foundation
2016.01 - 2020.01
- Cultured Human Primary Cells from patient samples to perform immunoassays.
- Conducted immunoassays (ELISA, ELISpot, Western blot) in malaria studies; supported in vivo malaria models to assess T-cell responses in vaccinated mice.
Academic Visitor
University of Oxford, The Jenner Institute
2018.01 - 2019.01
- Trained across antigen discovery and immunopeptidomics: HLA-I associated peptide identification via immunoaffinity purification and mass-spectrometry-based workflows.
Education
PhD - Immunology
Oswaldo Cruz Foundation / University of Oxford
Oxford 2016.01 - 2020.01
MSc - Molecular & Cellular Biology
Oswaldo Cruz Foundation
2014.01 - 2016.01
BSc - Bioscience
Centro Universitário UNA
2010.01 - 2013.01
Skills
- Antigen Discovery / TCR: Immunopeptidomics (HLA-I peptide IP → MS) to inform antigen selection; TCR workflows; target/biomarker hypothesis development
- Functional Pharmacology & MOA: T-cell activation, proliferation and cytotoxicity assays; MOA studies; combination screening; immunophenotyping of response/resistance
- Cytometry & Readouts: Multi-colour flow cytometry (up to 5-laser panels); ELISA/MSD/ELISpot/CBA; multiplex cytokines; robust QC and control strategy
- Genetic Modification & Primary Cells: Isolation and culture of patient-derived PBMCs; lentiviral transduction in primary human T cells and cell lines
- Preclinical Decision Support: Preclinical data packages; programme go/no-go recommendations; SOP authorship; GLP-standard documentation; stakeholder presentations
- Collaboration & Leadership: Cross-functional programme teamwork; training/mentoring; external/academic collaborations; introducing new techniques to improve workflows
Selected Publications
- Barbosa CRR et al. Identification of cross-stage, cross-species malaria CD8+ T-cell antigens. Manuscript under consideration- 2nd round revision. Nature (2026).
- Junqueira C, Barbosa CRR, et al. Cytotoxic CD8+ T cells recognise and kill Plasmodium vivax-infected reticulocytes. Nature Medicine 24:1330–1336 (2018).
References
References available upon request.
Timeline
Senior Research Associate
Evotec UK Ltd
2022.10 - 2026.03
Postdoctoral Researcher (T-Cell Immunology)
The Francis Crick Institute / King's College London
2021.01 - 2022.01
Academic Visitor
University of Oxford, The Jenner Institute
2018.01 - 2019.01
PhD - Immunology
Oswaldo Cruz Foundation / University of Oxford
2016.01 - 2020.01
PhD Researcher
Oswaldo Cruz Foundation
2016.01 - 2020.01
MSc - Molecular & Cellular Biology
Oswaldo Cruz Foundation
2014.01 - 2016.01
BSc - Bioscience
Centro Universitário UNA
2010.01 - 2013.01