Bharat Gadakh
Dundee,Angus
Summary
Experienced professional in synthetic organic chemistry and process development, with a strong track record in leadership and decision-making. Skilled in advanced analytical techniques, including HPLC, NMR, and LC-MS for effective troubleshooting and risk management. Proficient in various software tools such as Dotmatics, D360, and MS Office, enhancing research capabilities. Focused on fostering innovation through problem-solving and collaboration in diverse team settings.
Overview
17
17
years of professional experience
10
10
years of post-secondary education
Work history
Scientist/Medicinal Chemist
Centre for Targeted Protein Degradation
2022.10 - 2025.08
- Company Overview: University of Dundee, UK in collaboration with BoehringerIngelheim
- Design and synthesis of p.o. PROTACS with improved oral bioavailability, contributing to the project.
- Coordinate with CRO to ensure timely project execution, reducing lead times.
- Developed versatile synthetic pathways that led to improved synthetic efficiency by >2-fold
- University of Dundee, UK in collaboration with BoehringerIngelheim
Senior Scientist I
Selvita S.A.
2021.02 - 2022.09
- Company Overview: Krakow, Poland
- Led a team of 4 chemists in a high-paced research environment for the synthesis of target molecules and key intermediates.
- Communicated directly with all stakeholders, facilitating smooth project execution and alignment with project objectives.
- Scouted synthetic routes and planned execution, optimised the reaction conditions, and improved the process efficiency.
- Krakow, Poland
Scientific Manager (M1)
Aragen Life Sciences (GVK Bioscience)
2019.01 - 2020.12
- Company Overview: India
- Directed a team of 10 chemists in high-paced environment for synthesis of complex chemical compounds for pharmaceutical clients.
- Designed and optimized synthetic routes, coordinated with all stakeholders for smooth execution of the projects.
- Ensured on-time project delivery while meeting stringent deadlines.
- India
FWO Postdoctoral Fellow
KU Leuven
2015.12 - 2018.12
- Company Overview: Belgium
- Spearheaded the total synthesis of natural antibiotic albomycin and its congeners.
- Also accountable for manuscript writing.
- Supervised and trained Several Master's and PhD students.
- Belgium
IOCB Postdoctoral Fellow
Institute of Organic Chemistry & Biochemistry, Czech Academy of Sciences
2015.01 - 2015.11
- Synthesis of novel heterocycles as selective Pl4Kila inhibitors as a tool compound to understand biology and for antiviral therapy.
- Contributed intellectually to the project development, and data presentation internally and externally.
Postdoctoral Fellow
KU Leuven
2014.08 - 2014.12
- Company Overview: Belgium
- Led synthesis of nucleoside phosphoramidates as a tool compounds.
- Supervised and trained Master's and PhD students.
- Manuscript writing.
- Belgium
Research Fellow
Indian Institute of Technology, Delhi
2008.07 - 2010.05
- Synthesis of peptidomimetic and carbohydrate-peptide-based dendrimers for antimicrobial and drug delivery applications.
- Design and synthesis of peptide-based sortase inhibitors, improving antibacterial efficacy.
Education
Doctor of Philosophy - Medicinal Chemistry
KU Leuven
2010.01 - 2014.01
Master of Pharmaceutical Sciences - undefined
National Institute of Pharmaceutical Education & Research
2006.01 - 2008.01
Bachelor of Pharmaceutical Sciences - undefined
University of Pune
2002.01 - 2006.01
Skills
- Leadership
- Team Player
- Communication
- Creative & Problem Solver
- Decision-Making
- Adaptability & Quick Learner
- Positive Attitude
- Synthetic Organic Chemistry
- Scale-Up
- Diverse Synthetic experience
- Process Development & Optimization
- HPLC
- NMR
- LC-MS
- Troubleshooting
- Risk Mitigation
- Dotmatics
- D360
- MS Office
- Stardrop
- Knime
- Chemdraw
- Schrodinger Maestro
- Synthetic route design
Websites
Languages
English (Fluent)
Dutch (Basic)
Hindi (Bilingual)
Marathi (Native Speaker)
Custom
- Operational Efficiency & Team Growth: Coordinated with team and other stakeholders for operational efficiency, increasing FTEs from 30 to 50, and earned an Outstanding Achiever Award for project contributions.
- Scale-Up & Synthesis risk mitigation: Developed and optimised process protocol to obtain a few hundred grams of target molecules (4-step synthesis without chromatography), mitigating racemisation issue with improved yield.
- Route optimisation: Fine-tuned synthetic route to avoid side product formation, improved yield and easy purification led to improved efficiency.
Timeline
Scientist/Medicinal Chemist
Centre for Targeted Protein Degradation
2022.10 - 2025.08
Senior Scientist I
Selvita S.A.
2021.02 - 2022.09
Scientific Manager (M1)
Aragen Life Sciences (GVK Bioscience)
2019.01 - 2020.12
FWO Postdoctoral Fellow
KU Leuven
2015.12 - 2018.12
IOCB Postdoctoral Fellow
Institute of Organic Chemistry & Biochemistry, Czech Academy of Sciences
2015.01 - 2015.11
Postdoctoral Fellow
KU Leuven
2014.08 - 2014.12
Doctor of Philosophy - Medicinal Chemistry
KU Leuven
2010.01 - 2014.01
Research Fellow
Indian Institute of Technology, Delhi
2008.07 - 2010.05
Master of Pharmaceutical Sciences - undefined
National Institute of Pharmaceutical Education & Research
2006.01 - 2008.01
Bachelor of Pharmaceutical Sciences - undefined
University of Pune
2002.01 - 2006.01